Pinealon dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 7 published studies are one click away.
Animal studies only Bioregulators Also called EDR, Glu-Asp-Arg
Common use ranges
From user guides and clinic write-ups. No drug label exists, and no study has tested these amounts in people. Injected amounts range from 0.2 mg to 5 mg a day across four community guides, and some mention 5 to 10 mg. All agree on short courses of 10 to 20 days. No approved label exists.
- Half-life
- Not measured in any published study
- How it is taken
- Shot under the skin (subcutaneous), or oral capsule
- How long people use it
- 10 to 20 days in a row, sometimes up to 28 or 30. Repeated 1 to 3 times a year, with 2 to 3 months off between courses.
- Mixing used for the units
- 20 mg vial + 2 mL water. 1 unit on a U-100 insulin syringe = 100 mcg.
Pick your vial size and how much water you add. The units below change to match.
20 mg vial + 2 mL water: 1 unit = 100 mcg
| Tier | Each dose | Syringe units20 mg vial + 2 mL water | How often | Schedule | Vial lastsat this tier |
|---|---|---|---|---|---|
| Starting [1] | 200 mcg | 2 units 0.02 mL | once a day | 200 mcg under the skin once a night for 10 days. Another guide gives 100 to 300 mcg a day. | 6+ weeks |
| Typical [2] | 1 mg | 10 units 0.10 mL | once a day | 1 mg under the skin once a day for 10 to 20 days. One guide steps up from 1 mg to 2 mg over 20 days. | 20 days |
| Higher [3] | 5 mg | 50 units 0.50 mL | once a day | 5 mg under the skin once a day for 20 days. | 4 days |
| Oral Starting [4] | 200 mcg | Not a syringe dose | 2x a day | 0.2 mg by mouth twice a day, morning and afternoon, on an empty stomach, for 20 days. | |
| Oral Typical [5] | 5 mg | Not a syringe dose | once a day | 5 mg by mouth once a day for 10 days. | |
| Oral Higher [6] | 20 mg | Not a syringe dose | once a day | 20 mg by mouth once a day, often in the evening or 1 to 2 hours before bed, for 10 to 30 days. |
Good to know
- Often taken at night.
- One guide says not to go above 1 mg a day by injection.
- Oral and injected amounts are not the same thing and do not swap one for one.
Sources for these amounts
- Starting: PepperCalc, Pinealon · Peptide DB, Pinealon
- Typical: PepperCalc, Pinealon · Peptide Dosing Protocols, Pinealon
- Higher: Peptide DB, Pinealon
- Oral Starting: Peptide DB, Pinealon
- Oral Typical: PepperCalc, Pinealon
- Oral Higher: Peptide Assistant, Pinealon · Peptide Dosing Protocols, Pinealon
How long people use it: PepperCalc, Pinealon · Peptide Dosing Protocols, Pinealon · Peptide Assistant, Pinealon · Peptide DB, Pinealon
Half-life: PubMed search, pinealon or Glu-Asp-Arg with pharmacokinetics or half-life, no hits
Take the Pinealon chart with you
Get a one-page printable chart for Pinealon, with the syringe units for each vial and water mix. We can also email you when a new Pinealon study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 7 published studies
No human dose data. No published human study of Pinealon states an amount given. Every figure on this page comes from animal studies.
Amounts given to animals in studies
Read this first. People have been given pinealon by mouth in small Russian studies, but no abstract states the amount. Only two animal studies state a dose, so the most-used figure is thin.
Every study used for this page
Proof grade: Animal studies only. No human dose data has been published. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 26390612Meshchaninov et al, Adv Gerontol 2015 | Human, 32 adults aged 41 to 83 with organic brain syndrome (pinealon and vesugen arms) | Not stated in the abstract | By mouth (stated by citing paper PMID 34071923, not in this abstract) | Not in abstract | Not in abstract | Improved biological age markers. Vesugen did better than pinealon. Some prooxidant activity and lower CD34+ cells seen |
| PMID 23734521Bashkireva and Artamonova, Adv Gerontol 2012 | Human, 150 male truck drivers plus 150 metalworker controls | Not stated in the abstract | Not in abstract | Not in abstract | Not in abstract | Peptides improved psychoemotional scores. Best result with pinealon and vesugen combined |
| PMID 22567179Arutjunyan et al, Int J Clin Exp Med 2012 | Rat, pregnant female Wistar 180 to 200 g, with offspring tested | 10 mcg/kg body weight per day | Into the belly (IP) | Once a day | 5 days before methionine loading | Offspring learned better and had less oxidative damage in cerebellum neurons |
| PMID 34071923Khavinson et al, Pharmaceuticals 2021 | Mouse, 5xFAD Alzheimer model, 10 per group | 400 mcg/kg | Into the belly (IP) | Once a day | 2 months (age 2 to 4 months) | EDR prevented dendritic spine loss |
| PMID 21978084Khavinson et al, Rejuvenation Res 2011 | Rat cerebellar cells, neutrophils, PC12 cells | Not stated in the abstract | Added to culture | Not in abstract | Not in abstract | Cut reactive oxygen species and necrotic cell death |
| PMID 28509493Mendzheritsky et al, Adv Gerontol 2015 | Rat, 18-month-old, hypoxia and cold models (n not in abstract) | Not stated in the abstract | Not in abstract | Not in abstract | Not in abstract | Raised brain adrenergic and serotonin levels under stress. Cortexin had more antioxidant effect |
| PMID 21809624Mendzheritskii et al, Adv Gerontol 2011 | Rat, old, carotid occlusion model (n not in abstract) | Not stated in the abstract | Not in abstract | Given before occlusion | Not in abstract | Better survival after carotid occlusion |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
Is there a human dose for Pinealon?
No published human study of Pinealon states an amount given. The figures on this page come from animal studies only.
Where do these Pinealon numbers come from?
From 7 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Animal studies only.
How long does Pinealon stay in the body?
No published study has measured the half-life of Pinealon, so nobody knows exactly how long one dose stays in the blood.
Is this a recommendation for how much Pinealon to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.