Cortagen dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 6 published studies are one click away.
Animal studies only Bioregulators Also called AEDP, Ala-Glu-Asp-Pro
Common use ranges
From user guides and clinic write-ups. No drug label exists, and no study has tested these amounts in people. One guide gives 10 mg a day by injection and another gives 10 to 20 mg a day by mouth, both for 10 to 20 days. Sources are community and vendor guides only. No approved label exists in any country we found, and the published research comes almost entirely from one Russian research group.
Sources disagree, or there are very few. The amounts below come from a small number of guides, and they do not line up well. Treat every number on this page as uncertain, and check each source yourself.
- Half-life
- Not measured in any published study
- How it is taken
- Shot under the skin (subcutaneous), or oral capsule
- How long people use it
- 10 to 20 days in a row, then a break. The course is repeated every 3 to 6 months, which works out to 2 or 3 courses a year.
- Mixing used for the units
- 20 mg vial + 2 mL water. 1 unit on a U-100 insulin syringe = 100 mcg.
Includes amounts taken by mouth or in the nose. Those are not the same as a shot, see the route in each row below.
Pick your vial size and how much water you add. The units below change to match.
20 mg vial + 2 mL water: 1 unit = 100 mcg
| Tier | Each dose | Syringe units20 mg vial + 2 mL water | How often | Schedule | Vial lastsat this tier |
|---|---|---|---|---|---|
| Typical [1] | 10 mg | 100 units 1.00 mL | once a day | 10 mg under the skin once a day for 10 to 20 days. | 2 days |
| Oral Typical [2] | 10 mg | Not a syringe dose | once a day | 10 mg by mouth once a day, the low end of the 10 to 20 mg range, for 10 to 20 days. | |
| Oral Higher [3] | 20 mg | Not a syringe dose | once a day | 20 mg by mouth once a day, the top of the 10 to 20 mg range. | |
| Oral Maintenance [4] | 10 mg | Not a syringe dose | once a day | 10 mg by mouth once a day for a maintenance course. |
Good to know
- Injected courses run once a day, every day, for the length of the course. They are not taken all year.
- Oral strengths vary a lot by maker. Some packs list capsules, not milligrams, so the label on the box matters more than any range here.
Sources for these amounts
- Typical: Peptide Assistant, Cortagen
- Oral Typical: Peptide DB, Cortagen
- Oral Higher: Peptide DB, Cortagen
- Oral Maintenance: Peptide DB, Cortagen
How long people use it: Peptide Assistant, Cortagen · Peptide DB, Cortagen · Khavinson bioregulator guide (IPS News)
Half-life: Khavinson et al 2022, transport of ultrashort peptides (no half-life data)
Take the Cortagen chart with you
Get a one-page printable chart for Cortagen, with the syringe units for each vial and water mix. We can also email you when a new Cortagen study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 6 published studies
No human dose data. No published human study of Cortagen states an amount given. Every figure on this page comes from animal studies.
Amounts given to animals in studies
Read this first. Only one abstract states an amount (rat nerve repair, 2000). A Khavinson patent (not peer reviewed) describes 15 head-injury patients given 1 µg daily for 10 days, with no PubMed record.
Every study used for this page
Proof grade: Animal studies only. No human dose data has been published. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 11276314Turchaninova et al, Bull Exp Biol Med 2000 | Rat, cut and stitched sciatic nerve (n NOT IN ABSTRACT) | 10 mcg/kg | Into the muscle | Daily | 10 days | Nerve regrowth speed up 27%, nerve conduction speed up 40% |
| PMID 15159690Anisimov et al, Neuro Endocrinol Lett 2004 | Mouse, CBA female, 6 months (n NOT IN ABSTRACT) | Not stated in the abstract | Injection, site NOT IN ABSTRACT | Daily | 5 days | Changed expression of 234 heart gene clones (1.53% of 15,247) |
| PMID 21476278Zarubina and Shabanov, Eksp Klin Farmakol 2011 | Rat, chronic brain ischemia (n NOT IN ABSTRACT) | Not stated in the abstract | NOT IN ABSTRACT | NOT IN ABSTRACT | NOT IN ABSTRACT | Faster recovery of behavior, less lipid oxidation in brain |
| PMID 18239817Kozina, Bull Exp Biol Med 2007 | Rat (n NOT IN ABSTRACT) | Not stated in the abstract | Injection, site NOT IN ABSTRACT | NOT IN ABSTRACT | NOT IN ABSTRACT | Lowered lipid and protein oxidation products in serum and brain |
| PMID 16224591Kazakova et al, Bull Exp Biol Med 2005 | Rat (n NOT IN ABSTRACT) | Not stated in the abstract | More than one route, NOT IN ABSTRACT | NOT IN ABSTRACT | NOT IN ABSTRACT | Changed IL-2 gene activity in hypothalamus cells |
| PMID 12447482Kazakova et al, Bull Exp Biol Med 2002 | Mouse CBA spleen cells | Not stated in the abstract | Added to cell culture | NOT IN ABSTRACT | NOT IN ABSTRACT | Raised IL-2 mRNA, weaker than Vilon or Epitalon |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
Is there a human dose for Cortagen?
No published human study of Cortagen states an amount given. The figures on this page come from animal studies only.
Where do these Cortagen numbers come from?
From 6 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Animal studies only.
How long does Cortagen stay in the body?
No published study has measured the half-life of Cortagen, so nobody knows exactly how long one dose stays in the blood.
Is this a recommendation for how much Cortagen to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.