Sermorelin dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 8 published studies are one click away.
Small human studies Growth hormone axis Also called GRF 1-29
Common use ranges
From published clinic and pharmacy protocols. No drug label exists. No current adult label. The old Geref label was for children. Adult clinic protocols use 200 to 500 mcg at bedtime and adjust by IGF-1 blood tests.
- Half-life
- about 6 to 7 minutes in the vein
- How it is taken
- subcutaneous injection
- How long people use it
- 3 to 6 months or longer. After 6 months some use 5 days on, 2 days off.
- Mixing used for the units
- 9 mg vial + 2 mL water. 1 unit on a U-100 insulin syringe = 45 mcg.
Pick your vial size and how much water you add. The units below change to match.
9 mg vial + 2 mL water: 1 unit = 45 mcg
| Tier | Each dose | Syringe units9 mg vial + 2 mL water | How often | Schedule | Vial lastsat this tier |
|---|---|---|---|---|---|
| Starting [1] | 200 mcg | 4.4 units 0.04 mL | once a day | 200 to 300 mcg at bedtime on an empty stomach, weeks 1 to 8 | 6+ weeks |
| Typical [2] | 300 mcg | 6.7 units 0.07 mL | once a day | 300 to 400 mcg at bedtime, set by IGF-1 blood tests | about 4 weeks |
| Higher [3] | 500 mcg | 11.1 units 0.11 mL | once a day | Up to 500 mcg at bedtime | 18 days |
Good to know
- The old Geref label dose for children was 30 mcg per kg a day. Adult protocols do not use that formula.
Sources for these amounts
- Starting: Pure Peptide Clinic, sermorelin dosage
- Typical: Pure Peptide Clinic, sermorelin dosage
- Higher: Pure Peptide Clinic, sermorelin dosage
How long people use it: Pure Peptide Clinic, sermorelin dosage
Half-life: Geref 50 (sermorelin) product information, Ireland HPRA
Take the Sermorelin chart with you
Get a one-page printable chart for Sermorelin, with the syringe units for each vial and water mix. We can also email you when a new Sermorelin study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 8 published studies
Amounts given to people in studies
How it was given: Under the skin (SC)
Most trials were in children with low growth hormone. Adult studies were small.
Every study used for this page
Proof grade: Small human studies. Only small or uncontrolled human studies. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 83298251993 | Human, healthy men 19-43 yr (n = 30) | IV: 0.25 mcg/kg (lowest tested), 1-2 mcg/kg (maximal GH release). Intranasal: dose-dependent, maximum response at about 50 mcg/kg | IV or intranasal | Single doses. Repeated intranasal three times in one day | Acute | Lowest IV dose gave significant GH release. Intranasal bioavailability only 3-5% |
| PMID 13792561992 | Human, healthy old men, 68 yr (n = 10) | 0.5 mg (low) and 1 mg (high) per injection | SC | Twice daily | 14 days per dose, 14-day washout between | High dose raised 24-h GH and IGF-I to young-man levels. Low dose did not reach significance |
| PMID 90059761997 | Human, healthy elderly men 64-76 yr (n = 11) | 2 mg GHRH (as reported "nightly subcutaneous self-injections of 2 mg GHRH") | SC | Nightly, single injection | 6 weeks | Raised nocturnal GH release. No change in IGF-I. Small muscle strength gains |
| PMID 87725991996 | Human, prepubertal GH-deficient children (110 treated, 86 analysed) | 30 mcgrams/kg per day | SC | Once daily at bedtime | Up to 1 year | Height velocity 4.1 to 8.0 cm/yr at 6 mo and 7.2 cm/yr at 12 mo. 74% good responders at 6 mo. Open label, no control |
| PMID 77353671994 | Human, prepubertal GH-deficient children (n = 16) | 30 mcgrams/kg, one daily dose | SC | Once daily | 12 to 24 months | 11 of 16 responders, height velocity 3.4 to 6.5-6.8 cm/yr. Antibodies in some, no effect on growth |
| PMID 83298301993 | Human, GH-deficient children, hypothalamic origin (n = 60, 20 per group) | 30 or 60 mcgrams/kg/day (vs GH 0.1 IU/kg/day) | Abstract says "continuous infusion" in its closing line, route otherwise not stated | Daily | 6 months | Height velocity 9.2 and 9.3 cm/yr for 30 and 60 vs 14.6 with GH. No gain from the higher dose. Antibodies in 39 of 40 |
| PMID 79554601994 | Human, children with idiopathic short stature (n = 18, 17 analysed) | 20 mcgrams/kg (iv test dose 1 mcgram/kg) | SC | Twice daily | 12 months | Height velocity 4.8 to 7.2 cm/yr. Fasting glucose and insulin rose |
| PMID 83298281993 | Human, GH-deficient children (n = 8) | 50 mcgrams/kg (IV stimulation test 1 mcgram/kg) | Intranasal | Three times per day | 6 months | Absorption and effect fell with time, antibodies in 3 of 8. Not suitable in that form |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
What amounts of Sermorelin were used in human studies?
In the studies listed here, people were given from 0.25 mcg/kg IV (test dose) up to 60 mcg/kg per day (children). Adults: 2 mg nightly.. The amount used most often was 30 mcg/kg nightly (children). These are what study teams chose for their participants under supervision.
Where do these Sermorelin numbers come from?
From 8 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Small human studies.
How long does Sermorelin stay in the body?
Its half-life is about 6 to 7 minutes in the vein in people. Half-life is how long it takes for half of a dose to leave the blood. The effect can last longer than that.
Is this a recommendation for how much Sermorelin to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.