Ipamorelin dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 8 published studies are one click away.
Small human studies Growth hormone axis Also called NNC 26-0161
Common use ranges
From user guides and clinic write-ups. No drug label exists, and no study has tested these amounts in people. No drug label. Guides agree on 200 to 300 mcg a shot, once or twice a day. Some sites give the range per day instead of per shot, so check each source.
- Half-life
- about 2 hours
- How it is taken
- subcutaneous injection
- How long people use it
- 8 to 12 weeks on, then 4 weeks off.
- Mixing used for the units
- 10 mg vial + 2 mL water. 1 unit on a U-100 insulin syringe = 50 mcg.
Pick your vial size and how much water you add. The units below change to match.
10 mg vial + 2 mL water: 1 unit = 50 mcg
| Tier | Each dose | Syringe units10 mg vial + 2 mL water | How often | Schedule | Vial lastsat this tier |
|---|---|---|---|---|---|
| Starting [1] | 200 mcg | 4 units 0.04 mL | once a day | 200 mcg once a day before bed for the first 1 to 2 weeks | 6+ weeks |
| Typical [2] | 250 mcg | 5 units 0.05 mL | 2x a day | 200 to 300 mcg twice a day, before bed and in the morning, on an empty stomach | 20 days |
| Higher [3] | 300 mcg | 6 units 0.06 mL | 3x a day | 300 mcg 2 to 3 times a day | 11 days |
Good to know
- Often taken in the same shot as CJC-1295 (no DAC), about 100 mcg of each.
Sources for these amounts
- Starting: Pure Peptide Clinic, ipamorelin dosage
- Typical: Pure Peptide Clinic, ipamorelin dosage
- Higher: Pure Peptide Clinic, ipamorelin dosage
How long people use it: Pure Peptide Clinic, ipamorelin dosage
Half-life: Gobburu et al 1999, Pharm Res, PK-PD of ipamorelin in healthy men
Take the Ipamorelin chart with you
Get a one-page printable chart for Ipamorelin, with the syringe units for each vial and water mix. We can also email you when a new Ipamorelin study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 8 published studies
Amounts given to people in studies
How it was given: Into a vein (IV) only. No human study of under-the-skin use was found.
The phase 2 trial missed its main goal.
Amounts given to animals in studies
Every study used for this page
Proof grade: Small human studies. Only small or uncontrolled human studies. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 104966581999 | Human, healthy men (8 per dose level, 5 levels) | 4.21, 14.02, 42.13, 84.27 and 140.45 nmol/kg over 15 min | IV infusion | Single dose per level (dose escalation) | One infusion, 15 min | PK dose-proportional, half-life 2 h. GH released at all dose levels, single GH episode peaking 0.67 h |
| PMID 253310302014 | Human, postoperative bowel resection patients (117 enrolled, 114 analysed) | 0.03-mg/kg | IV infusion | Twice daily | Postoperative day 1 to 7 or hospital discharge | Phase 2 RCT vs placebo. Median time to first tolerated meal 25.3 h vs 32.6 h, p = 0.15 (not significant) |
| PMID 98498221998 | Rat (pentobarbital anaesthetised, n not in abstract) and swine (conscious, n not in abstract) | Potency only: rat ED50 = 80 +/- 42 nmol/kg, Emax 1545 +/- 250 ng GH/ml. Swine ED50 = 2.3 +/- 0.03 nmol/kg, Emax 65 +/- 0.2 ng GH/ml | Route not in abstract | Single dose | Acute | GH-selective: no ACTH or cortisol rise even at doses more than 200-fold above the GH ED50 |
| PMID 103733431999 | Rat, adult female (n not in abstract; body weight not stated, 0.25 kg assumed) | 0, 18, 90 and 450 mcg/day (per animal, split three times daily) | SC injection | Three times daily | 15 days | Dose-dependent rise in longitudinal bone growth rate (42 to 44, 50, 52 microm/day) and body weight gain |
| PMID 108288402000 | Rat, 13-week-old female Sprague-Dawley (IPA n=7) | 0.5 mg/kg per day (GHRP-6 0.5 mg/kg/day, GH 3.5 mg/kg/day as comparators) | SC, continuous by osmotic minipump | Continuous | 12 weeks | Increased bone mineral content and bone size. Volumetric BMD unchanged |
| PMID 117352442001 | Rat, 8-month-old female (n not in abstract; body weight not stated) | 100 mcg/kg (with methylprednisolone 9 mg/kg/day in some groups) | SC injection | Three times daily | 3 months | Counteracted steroid-induced loss of muscle strength and bone formation (periosteal formation rate up four-fold vs steroid alone) |
| PMID 106291651999 | Rat (n not in abstract; body weight not stated) | 0.4 or 1.6 mg/kg/day (with methylprednisolone 5.0 mg/kg) | IV (catheter) | Four times a day | 10 days | Reduced steroid-related body weight loss, IGF-I rose |
| PMID 192895672009 | Rat, fasted adult male, postoperative ileus model (n not in abstract) | 0.01 to 1 mg/kg (single IV bolus). Repetitive regimen 0.1 or 1 mg/kg. GHRP-6 20 mcg/kg as comparator | IV bolus | Single dose, or four doses a day at 3-h intervals | 2-day repetitive regimen, outcomes followed 48 h | Single 1 mg/kg shortened time to first bowel movement. Repetitive 0.1 or 1 mg/kg raised fecal output, food intake, weight gain |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
What amounts of Ipamorelin were used in human studies?
In the studies listed here, people were given from 4.21 nmol/kg IV, single dose up to 140.45 nmol/kg IV, single dose. The amount used most often was 0.03 mg/kg IV twice daily. These are what study teams chose for their participants under supervision.
Where do these Ipamorelin numbers come from?
From 8 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Small human studies.
How long does Ipamorelin stay in the body?
Its half-life is about 2 hours in people. Half-life is how long it takes for half of a dose to leave the blood. The effect can last longer than that.
Is this a recommendation for how much Ipamorelin to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.