Gonadorelin dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 6 published studies are one click away.
Small human studies Reproductive axis Also called GnRH, LHRH, Factrel, Lutrepulse, Kryptocur
Common use ranges
From user guides and clinic write-ups. No drug label exists, and no study has tested these amounts in people. Only one guide gives shot amounts, and it says no dose has been validated. The old Factrel label was a single 100 mcg test dose, not a course.
Sources disagree, or there are very few. The amounts below come from a small number of guides, and they do not line up well. Treat every number on this page as uncertain, and check each source yourself.
- Half-life
- about 4 minutes
- How it is taken
- subcutaneous injection
- How long people use it
- Ongoing, for as long as testosterone therapy continues.
- Mixing used for the units
- 5 mg vial + 2 mL water. 1 unit on a U-100 insulin syringe = 25 mcg.
Pick your vial size and how much water you add. The units below change to match.
5 mg vial + 2 mL water: 1 unit = 25 mcg
| Tier | Each dose | Syringe units5 mg vial + 2 mL water | How often | Schedule | Vial lastsat this tier |
|---|---|---|---|---|---|
| Starting [1] | 100 mcg | 4 units 0.04 mL | 3x a week | 100 mcg several times a week, alongside testosterone | 6+ weeks |
| Higher [2] | 300 mcg | 12 units 0.12 mL | once a day | Up to 300 mcg, as often as once a day | 16 days |
Good to know
- The old Factrel label used 100 mcg once, as a lab test of the pituitary gland.
Sources for these amounts
- Starting: Outliyr, gonadorelin report
- Higher: Outliyr, gonadorelin report
How long people use it: Outliyr, gonadorelin report
Half-life: Gonadorelin 100 micrograms powder for solution for injection, UK label section 5.2
Take the Gonadorelin chart with you
Get a one-page printable chart for Gonadorelin, with the syringe units for each vial and water mix. We can also email you when a new Gonadorelin study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 6 published studies
Amounts given to people in studies
How it was given: into a vein, by pump under the skin, or as a nose spray
Pump amounts are per pulse, so the daily total is many times larger.
Read this first. The 100 microgram figure is a one-time pituitary test, not a treatment. The pump studies were open-label or looked back at records, not randomized.
Every study used for this page
Proof grade: Small human studies. Only small or uncontrolled human studies. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 33704441Sansone et al, Hum Reprod 2021 | Human, adults tested by genotype | 100 mcgrams | Into a vein, bolus | One time | Single dose, blood at 30 and 45 minutes | LH rise after the test differed by FSHB gene type |
| PMID 26813133Liu et al, Zhonghua Yi Xue Za Zhi 2015 | Human, 5 women with low-gonadotropin infertility | 10 mcgrams per pulse | By pump, under the skin | One pulse every 90 minutes | At least 12 weeks | LH and estradiol rose, 4 of 5 had periods, 2 got pregnant |
| PMID 39210488Niu et al, Zhonghua Nan Ke Xue 2024 | Human, 45 men with congenital low-gonadotropin hypogonadism | 7 to 15 mcgrams per pulse | By pump | One pulse every 90 minutes | About 19 months on average | Sperm appeared in 33 of 45, 8 fathered children naturally |
| PMID 36336621Bogaert et al, J Pediatr Urol 2023 | Human, 14 of 20 boys treated after surgery for undescended testicles | 200 mcgrams, one spray in one nostril | Nose spray | Every other day | 6 to 8 months | Very low sperm counts in adulthood in 33% treated versus 67% untreated |
| PMID 30569789Zhang et al, Am J Mens Health 2019 | Human, 10 men on pump therapy, 18 on gonadotropin shots | Not stated in the abstract | By pump | Not in abstract | Up to 24 months | Sperm appeared sooner with the pump, median 6 months versus 14 |
| PMID 2122733Santoro, Am J Obstet Gynecol 1990 | Human, 109 women with hypothalamic absent periods | Not stated in the abstract | Into a vein, pulses | Not in abstract | Not in abstract | Ovulation in 91% and 96% of the two groups |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
What amounts of Gonadorelin were used in human studies?
In the studies listed here, people were given from 7 micrograms per pulse, one pulse every 90 minutes, by pump up to 200 micrograms as a nose spray, every other day for 6 to 8 months. The amount used most often was 100 micrograms, one time, into a vein. These are what study teams chose for their participants under supervision.
Where do these Gonadorelin numbers come from?
From 6 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Small human studies.
How long does Gonadorelin stay in the body?
Its half-life is about 4 minutes in people. Half-life is how long it takes for half of a dose to leave the blood. The effect can last longer than that.
Is this a recommendation for how much Gonadorelin to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.