Epithalon dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 7 published studies are one click away.
Animal studies only Longevity Also called Epitalon, AEDG
Common use ranges
From user guides and clinic write-ups. No drug label exists, and no study has tested these amounts in people. Sources agree well on 10 mg a day for 10 to 20 days, repeated once to a few times a year. Lower and higher amounts rest on single sources.
- Half-life
- Not measured in any published study
- How it is taken
- Shot under the skin (subcutaneous)
- How long people use it
- Short courses of 10 to 20 days in a row, then a long break. Most people repeat it 1 to 3 times a year. Continuous use is not advised.
- Mixing used for the units
- 50 mg vial + 2 mL water. 1 unit on a U-100 insulin syringe = 250 mcg.
Pick your vial size and how much water you add. The units below change to match.
50 mg vial + 2 mL water: 1 unit = 250 mcg
| Tier | Each dose | Syringe units50 mg vial + 2 mL water | How often | Schedule | Vial lastsat this tier |
|---|---|---|---|---|---|
| Low, longer course [1] | 2 mg | 8 units 0.08 mL | once a day | 2 mg once a day for 20 days, about 40 mg per course. | about 4 weeks |
| Starting [2] | 5 mg | 20 units 0.20 mL | once a day | 5 mg once a day, often at bedtime, for 10 to 20 days. | 10 days |
| Typical [3] | 10 mg | 40 units 0.40 mL | once a day | 10 mg once a day, often in the evening, for 10 to 20 days. | 5 days |
| Higher [4] | 15 mg | 60 units 0.60 mL | once a day | 15 mg once a day before bed for 10 to 20 days. | 3 days |
Good to know
- Epitalon has no approved label anywhere. The 5 to 10 mg doses trace back to Russian (Khavinson) clinic protocols.
- Bedtime or evening dosing is common, but it has not been tested against other times.
- Some people take it under the tongue at much higher doses (50 to 100 mg) because less gets absorbed. That use is not studied.
- Vials are sold as 10, 20 and 50 mg powder. A 50 mg vial often covers a full course.
Sources for these amounts
- Low, longer course: The Peptide Catalog, Epitalon buying guide
- Starting: Matrix clinic resource, Epitalon · Outliyr Epitalon report
- Typical: Outliyr Epitalon report · Matrix clinic resource, Epitalon · The Peptide Catalog, Epitalon buying guide
- Higher: Matrix clinic resource, Epitalon
How long people use it: Outliyr Epitalon report · Matrix clinic resource, Epitalon · The Peptide Catalog, Epitalon buying guide
Half-life: Overview of Epitalon, Int J Mol Sci 2025 (review)
Take the Epithalon chart with you
Get a one-page printable chart for Epithalon, with the syringe units for each vial and water mix. We can also email you when a new Epithalon study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 7 published studies
No human dose data. No published human study of Epithalon states an amount given. Every figure on this page comes from animal studies.
Amounts given to animals in studies
Read this first. Human reports exist, but none of their abstracts state the amount given. Most animal studies give a dose per animal, so the per-kg figures are estimates.
Every study used for this page
Proof grade: Animal studies only. No human dose data has been published. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 166345272006 | Mouse, female C3H/He, 1 yr old (n not in abstract; ~0.025 kg assumed) | 0.1 mcg (LOWEST) | injected (route not in abstract) | 5 times a week | 6.5 months | Fewer malignant tumors, no metastases |
| PMID 120498082002 | Rat, male LIO, 2 months old (n=80 in 4 groups; ~0.25 kg assumed) | 1 mcg | SC | 5 days a week | whole experiment | Fewer and smaller DMH-induced colon tumors |
| PMID 122095812002 | Mouse, female FVB/N HER-2/neu transgenic (n not in abstract) | 1 mcg/mouse | SC | 5 consecutive days every month | from age 2 months to death | Fewer, smaller mammary tumors |
| PMID 124598482002 | Mouse, female FVB/N HER-2/neu | 1 mg as printed in abstract, SC (**suspicious: other papers from same group say 1 mcg**) | SC | 5 times a week | from month 2 to death | Delayed aging, fewer breast tumors. Treat the "1 mg" figure as a probable unit error, not verified |
| PMID 145011832003 | Mouse, female SHR, 3 months to death (n=54 per group) | 1.0 mcg/mouse, stated "approximately 30-40 mcg/kg" | SC | 5 consecutive days every month | to natural death | No mean life span change, +13.3% life span of last 10% survivors, +12.3% max life span, fewer chromosome aberrations |
| PMID 159098152005 | Mouse, female SAMP-1 and SAMR-1 | 1 mkg (mcg)/mouse | SC | 5 times a week, monthly | to death | Prevented irregular estrous cycles; life span of last survivors reported |
| PMID 121952422002 | Campbell rats and human patients with retinal degeneration | Not stated in the abstract | not in abstract | not in abstract | not in abstract | "Positive clinical effect in 90%" of patients. Human count and dose not stated |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
Is there a human dose for Epithalon?
No published human study of Epithalon states an amount given. The figures on this page come from animal studies only.
Where do these Epithalon numbers come from?
From 7 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Animal studies only.
How long does Epithalon stay in the body?
No published study has measured the half-life of Epithalon, so nobody knows exactly how long one dose stays in the blood.
Is this a recommendation for how much Epithalon to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.